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Subsequently, activation of secondary pathways, including PKA and Epac2, alters the ion channel activity causing elevated levels of cytosolic Ca 2+ that enhances exocytosis of insulin-containing granules

Supplements also provide you with essential and non-essential benefits, which means your body either naturally can produce it (nonessential) so you are replacing or even enhancing present amounts, or you are providing it for your body from an outside source because it cannot produce it for itself (essential)